Tuesday, October 4, 2016

Paracetamol Poisoning: Learning Toxicology


A 42 YF ingested an unknown number of paracetamol tablets,
The following regarding paracetamol toxicity is/are true or false:

1-Histologic recovery lags behind clinical recovery and may take up to three months.

True, fact

2-Acute pancreatitis has been described in Stage 1.

False,
Stage 2

3-It is  suggested to treat with activated charcoal, 1 g/kg (maximum dose 50 g) by mouth for all patients who present within four hours .

True,
From Uptodate

4-Females are probably more protected than males via an increased supply and regeneration of glutathione and greater activity of conjugation enzymes .

False ,

Young children are probably protected via an increased supply and regeneration of glutathione and greater activity of conjugation enzymes 

5-Acute alcohol ingestion is not a risk factor for hepatotoxicity and may even be protective

True, fact
(From Uptodate)

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